publication . Article . Other literature type . 1997

A Dose–Response Analysis of the Reproductive Effects of a Single Gestational Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Male Long Evans Hooded Rat Offspring

L.E. Gray; J.S. Ostby; W.R. Kelce;
  • Published: 01 Sep 1997
Abstract
Male rats exposedin uteroto 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) display reduced fertility as a consequence of the direct action of TCDD on the epididymides, as well as delayed puberty and altered reproductive organ weights. The current study provides dose–response data for the reproductive effects of TCDD, administered during pregnancy, with an emphasis on the effects of TCDD on testicular, epididymal, and ejaculated sperm numbers. Long Evans Hooded rats were dosed by gavage with 0, 0.05, 0.20, or 0.80 μg TCDD/kg on Day 15 of gestation. After birth, growth, viability, and developmental landmarks were monitored in both male and female offspring. Shortly af...
Subjects
Medical Subject Headings: endocrine systemreproductive and urinary physiologyurogenital system
free text keywords: Toxicology, Pharmacology, Offspring, Pregnancy, medicine.disease, medicine, Sperm, Endocrinology, medicine.medical_specialty, Testicle, medicine.anatomical_structure, Spermatogenesis, Delayed puberty, medicine.symptom, Testosterone, Epididymis, Biology, Internal medicine
Related Organizations
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 1997

A Dose–Response Analysis of the Reproductive Effects of a Single Gestational Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Male Long Evans Hooded Rat Offspring

L.E. Gray; J.S. Ostby; W.R. Kelce;