publication . Conference object . Under curation

In-silico feedback control of a MIMO synthetic Toggle Switch via Pulse-Width Modulation

Guarino, Agostino; Fiore, Davide; di Bernardo, Mario;
Open Access
Abstract
Abstract The genetic toggle switch is a MIMO control system that can be controlled by varying the concentrations of two inducer molecules, aTc and IPTG, to achieve a desired level of expression of the two genes it comprises. It has been shown in Lugagne et al., Nature Communication (2017) that this can be accomplished through an open-loop external control strategy where the two inputs are selected as mutually exclusive periodic pulse waves of appropriate amplitude and duty-cycle. In this paper, we use a recently derived average model of the genetic toggle switch subject to these inputs to synthesize new feedback control approaches that adjust the inputs duty...
Persistent Identifiers
Funded by
EC| COSY-BIO
Project
COSY-BIO
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020
Download from
Open Access
ZENODO
Conference object
Provider: ZENODO
Any information missing or wrong?Report an Issue