publication . Article . 2004

New Therapeutic Strategies and Drug Candidates for Neurodegenerative Diseases: p53 and TNF‐α Inhibitors, and GLP‐1 Receptor Agonists

Greig, N. H.;
Open Access
  • Published: 01 Dec 2004 Journal: Annals of the New York Academy of Sciences, volume 1,035, pages 290-315 (issn: 0077-8923, Copyright policy)
  • Publisher: Wiley
Abstract
Abstract: Owing to improving preventative, diagnostic, and therapeutic measures for cardiovascular disease and a variety of cancers, the average ages of North Americans and Europeans continue to rise. Regrettably, accompanying this increase in life span, there has been an increase in the number of individuals afflicted with age-related neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and stroke. Although different cell types and brain areas are vulnerable among these, each disorder likely develops from activation of a common final cascade of biochemical and cellular events that eventually lead to neuronal dysfunction and death. In t...
Subjects
free text keywords: Glutamate receptor, Immunology, Tumor Necrosis Factor Decoy Receptors, Cytokine, medicine.medical_treatment, medicine, Glucagon-like peptide 1 receptor, Neurotrophin, biology.protein, biology, Disease, Receptor, Tumor necrosis factor alpha
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publication . Article . 2004

New Therapeutic Strategies and Drug Candidates for Neurodegenerative Diseases: p53 and TNF‐α Inhibitors, and GLP‐1 Receptor Agonists

Greig, N. H.;