publication . Article . 2020

Furthering genome design using models and algorithms

Joshua Rees-Garbutt; Jake Rightmyer; Jonathan R. Karr; Claire S. Grierson; Lucia Marucci;
Open Access
  • Published: 16 Oct 2020
Abstract
Highlights Models can investigate many more genome designs than laboratory research. Algorithms can search for genomes that optimise specific criteria. Together, models and algorithms can help engineers to design genomes. Algorithm-driven whole-cell model in silico designs could be viable in vivo. The genome design ecosystem needs improved modelling and design tools. Abstract Large-scale in silico genome designs are on the brink of being engineered in vivo, offering a potential paradigm shift for cellular research (previous designs relied on fractured available knowledge and in vivo engineering iteration) by integrating computational design, in silico models and...
Persistent Identifiers
Subjects
free text keywords: Genome, Cellular life, In silico, Algorithm, Paradigm shift, Computer science, Computational design
Funded by
EC| COSY-BIO
Project
COSY-BIO
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020 | RIA
Validated by funder
Communities
FET H2020FET OPEN: FET-Open research and innovation actions
FET H2020FET OPEN: Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
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