publication . Article . 1988

Acyclovir-induced renal failure

Mark H. Sawyer; David Webb; James E. Balow; Stephen E. Straus;
Open Access
  • Published: 01 Jun 1988
Abstract
Four patients with a chronic fatigue syndrome experienced five episodes of acute renal insufficiency associated with high-dose (500 mg/m2) intravenous acyclovir administered intravenously as one-hour infusions. Nephrotoxicity developed despite precautions to avoid volume contraction. Examination of the urinary sediment of three patients by polarizing microscopy showed birefringent needle-shaped crystals within leukocytes. In the most severely affected patient, a serum creatinine concentration of 8.6 mg/dl developed and the patient underwent percutaneous renal biopsy that revealed foci of interstitial inflammation without tubular necrosis. Urine, blood, and renal...
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free text keywords: Adverse effect, Acute kidney injury, medicine.disease, medicine, Aciclovir, medicine.drug, Kidney, medicine.anatomical_structure, Urology, medicine.medical_specialty, Obstructive Nephropathy, Crystalluria, medicine.symptom, Surgery, Creatinine, chemistry.chemical_compound, chemistry, business.industry, business, Nephrotoxicity
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