publication . Article . Other literature type . 2019

Tissue engineering of heart valves – challenges and opportunities

Malcova, Tatiana; Balutel, Tatiana; Ciubotaru, Anatol; Nacu, Viorel;
Open Access English
  • Published: 28 Nov 2019
<strong>Background:</strong> Heart valve disease is a clinically serious condition. The replacement of damaged valves practiced since the 1950’s is the ultimate treatment for end-stage heart failure caused by severe valve dysfunction. The choice of adequate prosthesis is challenging. Unfortunately, the treatment options available today do not satisfy completely physicians and scientists’ needs. Mechanical valves require long-term anticoagulation therapy because of poor hemocompatibility. Biological substitutes have better hemodynamics, but need replacement in ~ 10 years due to calcification and degeneration. In order to overcome the shortcomings of current treat...
free text keywords: tissue engineering of heart valve, decellularized scaffolds, hybrid starter matrices, lcsh:Medicine, lcsh:R
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Article . 2019
Provider: ZENODO
Other literature type . 2019
Provider: Datacite
Other literature type . 2019
Provider: Datacite
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