Design of Infusion Schemes for Neuroreceptor Imaging: Application to [11C]Flumazenil-PET Steady-State Study

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Feng, Ling; Svarer, Claus; Madsen, Karine; Ziebell, Morten; Dyssegaard, Agnete; Ettrup, Anders; Hansen, Hanne Demant; Lehel, Szabolcs; Yndgaard, Stig; Paulson, Olaf Bjarne; Knudsen, Gitte Moos; Pinborg, Lars Hageman;
  • Publisher: Hindawi Publishing Corporation
  • Journal: BioMed Research International, volume 2,016 (issn: 2314-6133, eissn: 2314-6141)
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.1155/2016/9132840, pmc: PMC4830710
  • Subject: Clinical Trial | Positron-Emission Tomography | /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 | Research Article | Young Adult | Medicine | Middle Aged | Models, Biological | Infusions, Intravenous | Feedback | R | Carbon Radioisotopes | Time Factors | /dk/atira/pure/researchoutput/pubmedpublicationtype/D016430 | Journal Article | Adult | Female | Flumazenil | Article Subject | Humans | Male | Metabolome | Sensory Receptor Cells

<p>This study aims at developing a simulation system that predicts the optimal study design for attaining tracer steady-state conditions in brain and blood rapidly. Tracer kinetics was determined from bolus studies and used to construct the system. Subsequently, the sys... View more
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