publication . Preprint . Article . Other literature type . 2020

Synchronisation of yeast cell cycle through quorum sensing coupling

Giansimone Perrino; Diego di Bernardo;
Open Access English
  • Published: 05 Apr 2020
  • Publisher: Cold Spring Harbor Laboratory
Abstract
<jats:title>Abstract</jats:title><jats:p>The cell cycle is present in all cells of all species and it is of fundamental importance in coordinating all the steps required for cell replication, including growth, DNA replication and cell division. Budding yeast is an unicellular organism characterised by a mother cell that buds to generate a daughter cell at each cell cycle. Each cell in a population buds at a different time. Despite its importance in biological applications, such as unravelling cell-cycle machinery mechanisms and production of valuable bioproducts, at present no yeast strain is capable of budding synchronously. To overcome this problem, we used co...
Subjects
free text keywords: Control and Systems Engineering, DNA replication, Cell biology, Yeast, Cell division, Cell, medicine.anatomical_structure, medicine, Cell cycle, Quorum sensing, Unicellular organism, biology.organism_classification, biology, Population, education.field_of_study, education
Funded by
EC| COSY-BIO
Project
COSY-BIO
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020 | RIA
Validated by funder
Communities
FET H2020FET OPEN: FET-Open research and innovation actions
FET H2020FET OPEN: Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
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18 references, page 1 of 2

Acar, M., Mettetal, J.T., and Van Oudenaarden, A. (2008). Stochastic switching as a survival strategy in uctuating environments. Nature genetics, 40(4), 471.

Beaumont, H.J., Gallie, J., Kost, C., Ferguson, G.C., and Rainey, P.B. (2009). Experimental evolution of bet hedging. Nature, 462(7269), 90. [OpenAIRE]

Charvin, G., Cross, F.R., and Siggia, E.D. (2009). Forced periodic expression of G1 cyclins phase-locks the budding yeast cell cycle. Proceedings of the National Academy of Sciences, 106(16), 6632{6637.

Danino, T., Mondragon-Palomino, O., Tsimring, L., and Hasty, J. (2010). A synchronized quorum of genetic clocks. Nature, 463(7279), 326. [OpenAIRE]

Davis, P.K., Ho, A., and Dowdy, S.F. (2001). Biological methods for cell-cycle synchronization of mammalian cells. BioTechniques, 30(6), 1322{1331.

Di Talia, S., Skotheim, J.M., Bean, J.M., Siggia, E.D., and Cross, F.R. (2007). The e ects of molecular noise and size control on variability in the budding yeast cell cycle. Nature, 448(7156), 947. [OpenAIRE]

Khammash, M., Di Bernardo, M., and Di Bernardo, D. (2019). Cybergenetics: Theory and methods for genetic control system. In 2019 IEEE 58th Conference on Decision and Control (CDC), 916{926.

Kuramoto, Y. (1984). Chemical Oscillations, Waves, and Turbulence. Springer Series in Synergetics. SpringerVerlag.

Li, F., Long, T., Lu, Y., Ouyang, Q., and Tang, C. (2004). The yeast cell-cycle network is robustly designed. Proceedings of the National Academy of Sciences, 101(14), 4781{4786.

Ma, Y. and Yoshikawa, K. (2009). Self-sustained collective oscillation generated in an array of nonoscillatory cells. Phys. Rev. E, 79, 046217.

Miller, M.B. and Bassler, B.L. (2001). Quorum sensing in bacteria. Annual Review of Microbiology, 55(1), 165{ 199.

Perrino, G., Fiore, D., Napolitano, S., di Bernardo, M., and di Bernardo, D. (2019a). Towards feedback control of the cell-cycle across a population of yeast cells. In 2019 18th European Control Conference (ECC), 2644{ 2650.

Perrino, G., Fiore, D., Napolitano, S., Galdi, F., La Regina, A., di Bernardo, M., and di Bernardo, D. (2019b). Feedback control promotes synchronisation of the cell-cycle across a population of yeast cells. In 2019 IEEE 58th Conference on Decision and Control (CDC), 933{938.

Rahi, S.J., Pecani, K., Ondracka, A., Oikonomou, C., and Cross, F.R. (2016). The CDK-APC/c oscillator predominantly entrains periodic cell-cycle transcription. Cell, 165(2), 475{487. [OpenAIRE]

Sacre, P. and Sepulchre, R. (2014). Sensitivity analysis of oscillator models in the space of phase-response curves: Oscillators as open systems. IEEE Control Systems Magazine, 34(2), 50{74. [OpenAIRE]

18 references, page 1 of 2
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