publication . Other literature type . Article . 2019

DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF KETOPROFEN IN CAPSULE AND TABLET DOSAGE FORMS

Name: DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF KETOPROFEN IN CAPSULE AND TABLET DOSAGE FORMS
Creator: A. A. Hassan1, S. W. Shantier2*

A. A. Hassan1, S. W. Shantier2*;

Open Access

Published: 05 Feb 2019

Publisher: Zenodo

Summary

Abstract

A simple and sensitive UV-spectrophotometric method for the assay of the poorly water-soluble ketoprofen in its dosage form was developed using 1M NaHCO3 as diluent. Ketoprofen exhibited maximum absorbance at 260 nm. Validation of the method was performed according to ICH guidelines. It was found to be linear in the concentration range of 2.5-15 μg/ml (R2=0.998) with low values of limit of detection and quantification (0.78μg/ml, 2.35μg/ml).The application of the proposed method for assay of ketoprofen (tablets and capsules) gave good results 99.08%±0.58 and 99.28%± 0.82, respectively.