publication . Other literature type . Article . 2018

Synthesis Of Novel (R)-5-Bromo-3-(N-Methylpyrrolidine-2-Yl-Methyl)-1H (Substituted)-Indole Derivatives As Potential Cox-2 Inhibitors Via Japp-Klingemann And Fischer Indole Cyclization Reactions

Name: Synthesis Of Novel (R)-5-Bromo-3-(N-Methylpyrrolidine-2-Yl-Methyl)-1H (Substituted)-Indole Derivatives As Potential Cox-2 Inhibitors Via Japp-Klingemann And Fischer Indole Cyclization Reactions
Creator: Tasleem*, P. Shyam Sundar

Tasleem*, P. Shyam Sundar;

Open Access English

Published: 07 Jan 2018

Publisher: Zenodo

Summary

Abstract

A series of novel (R)-5-bromo-3-(N-methylpyrrolidine-2-yl-methyl)-1H (substituted)-indole (T1-T5) derivates were synthesized by electrophilic substitution at 1st position of (R)-5-bromo-3-(N-methylpyrrolidine-2-yl-methyl)-1Hindole with various halides. The starting material (R)-5-bromo-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole was synthesized from 4-bromo aniline by multistep synthesis. The synthesized compounds were characterized by IR, 1H NMR and MASS spectroscopy and newly synthesized compounds were evaluated for their analgesic activity by tail immersion technique using wistar albino mice. Among the synthesized compounds T3, T4, T5.have shown significant...

Persistent Identifiers

doi: 10.5281/zenodo.1136256 , 10.5281/zenodo.1136257

Subjects

free text keywords: Indole derivatives; Analgesic activity; Tail immersion technique.

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