SYNTHESIS OF NOVEL (R)-5-BROMO-3-(N-METHYLPYRROLIDINE-2-YL-METHYL)-1H (SUBSTITUTED)-INDOLE DERIVATIVES AS POTENTIAL COX-2 INHIBITORS VIA JAPP-KLINGEMANN AND FISCHER INDOLE CYCLIZATION REACTIONS

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Tasleem*, P. Shyam Sundar, R. Vasanthi;
(2018)

A series of novel (R)-5-bromo-3-(N-methylpyrrolidine-2-yl-methyl)-1H (substituted)-indole (T1-T5) derivates were synthesized by electrophilic substitution at 1st position of (R)-5-bromo-3-(N-methylpyrrolidine-2-yl-methyl)-1Hindole with various halides. The starting mate... View more
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