publication . Article . 2012

Programming of DNA Methylation Patterns.

Howard Cedar; Yehudit Bergman;
Open Access English
Abstract
DNA methylation represents a form of genome annotation that mediates gene repression by serving as a maintainable mark that can be used to reconstruct silent chromatin following each round of replication. During development, germline DNA methylation is erased in the blastocyst, and a bimodal pattern is established anew at the time of implantation when the entire genome gets methylated while CpG islands are protected. This brings about global repression and allows housekeeping genes to be expressed in all cells of the body. Postimplantation development is characterized by stage- and tissue-specific changes in methylation that ultimately mold the epigenetic patter...
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Subjects
free text keywords: Chromatin, Epigenetics of physical exercise, Genetics, Biology, DNA methylation, Histone methylation, RNA-Directed DNA Methylation, Reprogramming, Epigenomics, Epigenetics
Related Organizations
Funded by
EC| METSTEM
Project
METSTEM
DNA methylation in stem cells
  • Funder: European Commission (EC)
  • Project Code: 268614
  • Funding stream: FP7 | SP2 | ERC
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