publication . Article . 2008

Estimating drug efficacy and viral dynamic parameters: HIV and HCV

Ruy M. Ribeiro; Alan S. Perelson;
Open Access
  • Published: 15 Oct 2008
  • Publisher: Wiley
Abstract
Mathematical models have proven valuable in understanding the in vivo dynamics of human immunodeficiency virus type 1 (HIV-1), the virus that causes AIDS, and hepatitis C virus (HCV), the virus that causes hepatitis C infection. By comparing mathematical models with the data obtained from patients being treated with antiviral drugs, it has been possible to determine many quantitative features of these infections. The most dramatic finding has been that even though AIDS and hepatitis C are diseases that occur on a timescale of one or more decades, there are very rapid dynamical processes that occur on timescales of hours to days, as well as slower processes that ...
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free text keywords: Human immunodeficiency virus (HIV), medicine.disease_cause, medicine, Virus, Hepatitis C virus, Immunology, Virology, Efficacy, Acquired immunodeficiency syndrome (AIDS), medicine.disease, business.industry, business, Hepatitis C, In vivo, Dynamical modeling
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