publication . Article . 2008

Estimating drug efficacy and viral dynamic parameters: HIV and HCV.

Ruy Ribeiro;
Open Access
  • Published: 15 Oct 2008 Journal: Statistics in Medicine, volume 27, pages 4,647-4,657 (issn: 0277-6715, eissn: 1097-0258, Copyright policy)
  • Publisher: Wiley
Abstract
Mathematical models have proven valuable in understanding the in vivo dynamics of human immunodeficiency virus type 1 (HIV-1), the virus that causes AIDS, and hepatitis C virus (HCV), the virus that causes hepatitis C infection. By comparing mathematical models with the data obtained from patients being treated with antiviral drugs, it has been possible to determine many quantitative features of these infections. The most dramatic finding has been that even though AIDS and hepatitis C are diseases that occur on a timescale of one or more decades, there are very rapid dynamical processes that occur on timescales of hours to days, as well as slower processes that ...
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