publication . Article . 1993

Are binge drinkers more at risk of developing brain damage?

W A Hunt;
Open Access
  • Published: 01 Nov 1993 Journal: Alcohol, volume 10, pages 559-561 (issn: 0741-8329, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Alcoholism is often associated with brain damage and cognitive deficits. Because drinking patterns can include periods of alcohol consumption followed by abstinence, binge drinking may enhance the possibility of brain damage. Chronic administration of ethanol leads to upregulation of N-methyl-d-aspartate (NMDA) and calcium receptors and increased release of glucocorticoids. NMDA-mediated mechanisms and glucocorticoid actions on the hippocampus are associated with brain damage. Thus, ethanol withdrawal may make the brain more vulnerable to damage from these mechanisms, especially with binge drinking. Therapeutic adjuncts for treating ethanol withdrawal, ...
Subjects
free text keywords: Toxicology, Biochemistry, Behavioral Neuroscience, Health(social science), Neurology, General Medicine, Abstinence, media_common.quotation_subject, media_common, NMDA receptor, Toxicity, Diabetes mellitus, medicine.disease, medicine, Hippocampus, Anesthesia, Glucocorticoid, medicine.drug, Endocrinology, medicine.medical_specialty, Brain damage, medicine.symptom, Binge drinking, Internal medicine, business.industry, business
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