publication . Article . Other literature type . 2002

Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress.

Tsigos, Constantine; Chrousos, George P;
Open Access
  • Published: 01 Nov 2002
Abstract
Abstract The stress system coordinates the adaptive responses of the organism to stressors of any kind. 1 The main components of the stress system are the corticotropin-releasing hormone (CRH) and locus ceruleus–norepinephrine (LC/NE)-autonomic systems and their peripheral effectors, the pituitary–adrenal axis, and the limbs of the autonomic system. Activation of the stress system leads to behavioral and peripheral changes that improve the ability of the organism to adjust homeostasis and increase its chances for survival. The CRH and LC/NE systems stimulate arousal and attention, as well as the mesocorticolimbic dopaminergic system, which is involved in anticip...
Subjects
Medical Subject Headings: endocrine systemhormones, hormone substitutes, and hormone antagonists
free text keywords: Clinical Psychology, Psychiatry and Mental health, Neuroendocrinology, Somatostatin, Hypothalamic–pituitary–adrenal axis, medicine.anatomical_structure, medicine, Psychoneuroimmunology, Corticotropin-releasing hormone, Dopaminergic, Central nucleus of the amygdala, Internal medicine, medicine.medical_specialty, Endocrinology, Psychology, Autonomic nervous system
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