publication . Article . Other literature type . 2017

Sampling strategies to capture single-cell heterogeneity

Satwik Rajaram; Heinrich, Louise E.; Gordan, John D.; Jayant Avva; Bonness, Kathy M.; Witkiewicz, Agnieszka K.; Malter, James S.; Atreya, Chloe E.; Warren, Robert S.; Lani F. Wu; ...
Open Access
  • Published: 04 Sep 2017
  • Country: United States
Abstract
Advances in single-cell technologies have highlighted the prevalence and biological significance of cellular heterogeneity. A critical question is how to design experiments that faithfully capture the true range of heterogeneity from samples of cellular populations. Here, we develop a data-driven approach, illustrated in the context of image data, that estimates the sampling depth required for prospective investigations of single-cell heterogeneity from an existing collection of samples. This dataset contains the tissue image data needed to reproduce Fig.1. This is supplementary data associated with the paper "Sampling strategies to capture single-cell heterogen...
Subjects
free text keywords: Sampling, Cellular Heterogeneity, Microscopy, Cell Line, Humans, Adenocarcinoma, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Cell Culture Techniques, Gene Expression Regulation, Neoplastic, Single-Cell Analysis, Biomarkers, Tumor, Mental Health, 1.1 Normal biological development and functioning, Generic Health Relevance, Developmental Biology, Biological Sciences, Technology, Medical and Health Sciences
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publication . Article . Other literature type . 2017

Sampling strategies to capture single-cell heterogeneity

Satwik Rajaram; Heinrich, Louise E.; Gordan, John D.; Jayant Avva; Bonness, Kathy M.; Witkiewicz, Agnieszka K.; Malter, James S.; Atreya, Chloe E.; Warren, Robert S.; Lani F. Wu; ...