publication . Article . 2005

Cancer risk associated with receipt of vaccines contaminated with simian virus 40: Epidemiologic research

Eric A. Engels;
Open Access
  • Published: 01 May 2005
Simian virus (SV)40 was an accidental contaminant of poliovirus vaccines used widely in the USA and other countries in 1955-1962. Exposure to SV40 via contaminated vaccines has led to concern as SV40 causes cancer in laboratory animals. In addition, some laboratories, although not all, have detected SV40 DNA in human tumors including mesothelioma, certain brain tumors, osteosarcoma and non-Hodgkin's lymphoma. This article reviews the data regarding contamination of poliovirus vaccines with SV40 and summarizes the results from epidemiologic studies of vaccine recipients. Long-term follow-up studies have not revealed recipients of SV40-contaminated poliovirus vacc...
Medical Subject Headings: viruses
free text keywords: Immunology, Molecular Medicine, Pharmacology, Drug Discovery, Adenovirus vaccine, medicine.drug, medicine, Non-Hodgkin's lymphoma, medicine.disease, Mesothelioma, Contamination, Cancer, Virus, Simian, biology.organism_classification, biology, Virology, Lymphoma
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