publication . Article . Other literature type . 2016

TSPO imaging in parkinsonian disorders

Alexander Gerhard;
Open Access English
  • Published: 11 Apr 2016 Journal: Clinical and Translational Imaging, volume 4, issue 3, pages 183-190 (issn: 2281-5872, Copyright policy)
  • Publisher: Springer Nature
  • Country: Switzerland
Abstract
Microglial activation is a key aspect of the neuroinflammatory process in neurodegenerative disorders including idiopathic and atypical parkinsonian disorders. With positron emission tomography (PET) it has become possible to image this phenomenon in vivo and over the last years patterns of microglia activation corresponding with the known distribution of neuropathological changes in these disorders have been demonstrated using this technique. In addition the effects of interventions aimed at suppressing microglia activation as part of interventional trials have successfully been demonstrated. Current research aims at evaluating PET tracers for microglial activa...
Subjects
free text keywords: Neuroinflammation, Microglia, TSPO, Parkinson's disease, [11C]-(R)-PK11195- PET, Radiology Nuclear Medicine and imaging, medicine.anatomical_structure, medicine, In vivo, Positron emission tomography, medicine.diagnostic_test, medicine.disease, Pathology, medicine.medical_specialty, business.industry, business, Review Article, Parkinson’s disease
Related Organizations
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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publication . Article . Other literature type . 2016

TSPO imaging in parkinsonian disorders

Alexander Gerhard;