publication . Article . Other literature type . 2017

Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women.

Menni, Cristina; Zierer, Jonas; Pallister, Tess; Jackson, Matthew A.; Long, Tao; Mohney, Robert P.; Steves, Claire J.; Spector, Tim D.; Valdes, Ana M.;
Open Access English
  • Published: 11 Sep 2017
  • Country: United Kingdom
Abstract
Abstract Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Bet...
Subjects
free text keywords: Journal Article, Medicine, R, Science, Q, Article, Composition (visual arts), N-Carbamylglutamate, Biology, Metabolite, chemistry.chemical_compound, chemistry, Metabolomics, Food science, Confounding, Microbiome, Food frequency, Lachnospiraceae, Biochemistry
Related Organizations
Funded by
RCUK| MICA: Ancestry and biological Informative Markers for stratification of HYpertension: The AIM HY study
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: MR/M016560/1
  • Funding stream: MRC
,
EC| HEALS
Project
HEALS
Health and Environment-wide Associations based on Large population Surveys
  • Funder: European Commission (EC)
  • Project Code: 603946
  • Funding stream: FP7 | SP1 | ENV
,
WT
Project
  • Funder: Wellcome Trust (WT)
,
NIH| Development of immunization strategies to reshape pathogenic microbiomes
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1DP2OD007444-01
  • Funding stream: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
81 references, page 1 of 6

Ortega, JF. Dietary supplementation with omega-3 fatty acids and oleate enhances exercise training effects in patients with metabolic syndrome. Obesity (Silver Spring). 2016; 24: 1704-1711 [OpenAIRE] [PubMed] [DOI]

Howe, P, Buckley, J. Metabolic health benefits of long-chain omega-3 polyunsaturated fatty acids. Military medicine. 2014; 179: 138-143 [OpenAIRE] [PubMed] [DOI]

Wurtz, P. Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts. Circulation. 2015; 131: 774-785 [OpenAIRE] [PubMed] [DOI]

Bonaa, KH, Bjerve, KS, Nordoy, A. Docosahexaenoic and eicosapentaenoic acids in plasma phospholipids are divergently associated with high density lipoprotein in humans. Arteriosclerosis and thrombosis: a journal of vascular biology. 1992; 12: 675-681 [PubMed] [DOI]

Oliveira, V. Diets Containing alpha-Linolenic (omega3) or Oleic (omega9) Fatty Acids Rescues Obese Mice From Insulin Resistance. Endocrinology. 2015; 156: 4033-4046 [OpenAIRE] [PubMed] [DOI]

Ogawa, S. Eicosapentaenoic acid improves glycemic control in elderly bedridden patients with type 2 diabetes. The Tohoku journal of experimental medicine. 2013; 231: 63-74 [PubMed] [DOI]

Muldoon, MF. Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults. The Journal of nutrition. 2013; 143: 1414-1420 [OpenAIRE] [PubMed] [DOI]

Casanova, MA. Omega-3 fatty acids supplementation improves endothelial function and arterial stiffness in hypertensive patients with hypertriglyceridemia and high cardiovascular risk. Journal of the American Society of Hypertension: JASH. 2017; 11: 10-19 [OpenAIRE] [PubMed] [DOI]

Barbosa, MM, Melo, AL, Damasceno, NR. The benefits of omega-3 supplementation depend on adiponectin basal level and adiponectin increase after the supplementation: A randomized clinical trial. Nutrition. 2017; 34: 7-13 [PubMed] [DOI]

Rajaei, E. The Effect of Omega-3 Fatty Acids in Patients With Active Rheumatoid Arthritis Receiving DMARDs Therapy: Double-Blind Randomized Controlled Trial. Global journal of health science. 2015; 8: 18-25 [OpenAIRE] [PubMed] [DOI]

Jiang, J. Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on Major Eicosanoids: A Systematic Review and Meta-Analysis from 18 Randomized Controlled Trials. PloS one. 2016; 11: e0147351 [OpenAIRE] [PubMed] [DOI]

Mosca, L. Usefulness of Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) in Women to Lower Triglyceride Levels (Results from the MARINE and ANCHOR Trials). The American journal of cardiology. 2017; 119: 397-403 [OpenAIRE] [PubMed] [DOI]

Kristensen, S. The effect of marine n-3 polyunsaturated fatty acids on cardiac autonomic and hemodynamic function in patients with psoriatic arthritis: a randomised, double-blind, placebo-controlled trial. Lipids in health and disease. 2016; 15: 216 [OpenAIRE] [PubMed] [DOI]

Arnold, LE. Omega-3 Fatty Acid Plasma Levels Before and After Supplementation: Correlations with Mood and Clinical Outcomes in the Omega-3 and Therapy Studies. Journal of child and adolescent psychopharmacology. 2017; 27: 223-233 [OpenAIRE] [PubMed] [DOI]

Pompili, M. Polyunsaturated fatty acids and suicide risk in mood disorders: A systematic review. Progress in neuro-psychopharmacology & biological psychiatry. 2017; 74: 43-56 [OpenAIRE] [PubMed] [DOI]

81 references, page 1 of 6
Abstract
Abstract Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Bet...
Subjects
free text keywords: Journal Article, Medicine, R, Science, Q, Article, Composition (visual arts), N-Carbamylglutamate, Biology, Metabolite, chemistry.chemical_compound, chemistry, Metabolomics, Food science, Confounding, Microbiome, Food frequency, Lachnospiraceae, Biochemistry
Related Organizations
Funded by
RCUK| MICA: Ancestry and biological Informative Markers for stratification of HYpertension: The AIM HY study
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: MR/M016560/1
  • Funding stream: MRC
,
EC| HEALS
Project
HEALS
Health and Environment-wide Associations based on Large population Surveys
  • Funder: European Commission (EC)
  • Project Code: 603946
  • Funding stream: FP7 | SP1 | ENV
,
WT
Project
  • Funder: Wellcome Trust (WT)
,
NIH| Development of immunization strategies to reshape pathogenic microbiomes
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1DP2OD007444-01
  • Funding stream: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
81 references, page 1 of 6

Ortega, JF. Dietary supplementation with omega-3 fatty acids and oleate enhances exercise training effects in patients with metabolic syndrome. Obesity (Silver Spring). 2016; 24: 1704-1711 [OpenAIRE] [PubMed] [DOI]

Howe, P, Buckley, J. Metabolic health benefits of long-chain omega-3 polyunsaturated fatty acids. Military medicine. 2014; 179: 138-143 [OpenAIRE] [PubMed] [DOI]

Wurtz, P. Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts. Circulation. 2015; 131: 774-785 [OpenAIRE] [PubMed] [DOI]

Bonaa, KH, Bjerve, KS, Nordoy, A. Docosahexaenoic and eicosapentaenoic acids in plasma phospholipids are divergently associated with high density lipoprotein in humans. Arteriosclerosis and thrombosis: a journal of vascular biology. 1992; 12: 675-681 [PubMed] [DOI]

Oliveira, V. Diets Containing alpha-Linolenic (omega3) or Oleic (omega9) Fatty Acids Rescues Obese Mice From Insulin Resistance. Endocrinology. 2015; 156: 4033-4046 [OpenAIRE] [PubMed] [DOI]

Ogawa, S. Eicosapentaenoic acid improves glycemic control in elderly bedridden patients with type 2 diabetes. The Tohoku journal of experimental medicine. 2013; 231: 63-74 [PubMed] [DOI]

Muldoon, MF. Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults. The Journal of nutrition. 2013; 143: 1414-1420 [OpenAIRE] [PubMed] [DOI]

Casanova, MA. Omega-3 fatty acids supplementation improves endothelial function and arterial stiffness in hypertensive patients with hypertriglyceridemia and high cardiovascular risk. Journal of the American Society of Hypertension: JASH. 2017; 11: 10-19 [OpenAIRE] [PubMed] [DOI]

Barbosa, MM, Melo, AL, Damasceno, NR. The benefits of omega-3 supplementation depend on adiponectin basal level and adiponectin increase after the supplementation: A randomized clinical trial. Nutrition. 2017; 34: 7-13 [PubMed] [DOI]

Rajaei, E. The Effect of Omega-3 Fatty Acids in Patients With Active Rheumatoid Arthritis Receiving DMARDs Therapy: Double-Blind Randomized Controlled Trial. Global journal of health science. 2015; 8: 18-25 [OpenAIRE] [PubMed] [DOI]

Jiang, J. Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on Major Eicosanoids: A Systematic Review and Meta-Analysis from 18 Randomized Controlled Trials. PloS one. 2016; 11: e0147351 [OpenAIRE] [PubMed] [DOI]

Mosca, L. Usefulness of Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) in Women to Lower Triglyceride Levels (Results from the MARINE and ANCHOR Trials). The American journal of cardiology. 2017; 119: 397-403 [OpenAIRE] [PubMed] [DOI]

Kristensen, S. The effect of marine n-3 polyunsaturated fatty acids on cardiac autonomic and hemodynamic function in patients with psoriatic arthritis: a randomised, double-blind, placebo-controlled trial. Lipids in health and disease. 2016; 15: 216 [OpenAIRE] [PubMed] [DOI]

Arnold, LE. Omega-3 Fatty Acid Plasma Levels Before and After Supplementation: Correlations with Mood and Clinical Outcomes in the Omega-3 and Therapy Studies. Journal of child and adolescent psychopharmacology. 2017; 27: 223-233 [OpenAIRE] [PubMed] [DOI]

Pompili, M. Polyunsaturated fatty acids and suicide risk in mood disorders: A systematic review. Progress in neuro-psychopharmacology & biological psychiatry. 2017; 74: 43-56 [OpenAIRE] [PubMed] [DOI]

81 references, page 1 of 6
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publication . Article . Other literature type . 2017

Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women.

Menni, Cristina; Zierer, Jonas; Pallister, Tess; Jackson, Matthew A.; Long, Tao; Mohney, Robert P.; Steves, Claire J.; Spector, Tim D.; Valdes, Ana M.;