REVIEW ON IMIDAZOPYRIDINE DERIVATIVES AS POTENT REVERSIBLE INHIBITORS OF THE GASTRIC H+, K+-ATPASE

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Ravindra S. Sonawane1*, Avinash V. Patil2;
(2017)

The gastric H+, K+-ATPase is the preferred target for acid suppression. PPIs are acid-activated prodrug that requires acid protection. Once acid-activated, PPIs bind to cysteine of the ATPase, resulting in covalent, long-lasting inhibition. The currently available PPIs ... View more
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