publication . Other literature type . Article . 1997

A Genomic Perspective on Protein Families

Koonin, E. V.; Tatusov, R. L.; Lipman, D. J.;
  • Published: 24 Oct 1997
  • Publisher: American Association for the Advancement of Science (AAAS)
Abstract
In order to extract the maximum amount of information from the rapidly accumulating genome sequences, all conserved genes need to be classified according to their homologous relationships. Comparison of proteins encoded in seven complete genomes from five major phylogenetic lineages and elucidation of consistent patterns of sequence similarities allowed the delineation of 720 clusters of orthologous groups (COGs). Each COG consists of individual orthologous proteins or orthologous sets of paralogs from at least three lineages. Orthologs typically have the same function, allowing transfer of functional information from one member to an entire COG. This relation a...
Subjects
Medical Subject Headings: fungihuman activities
free text keywords: Multidisciplinary, Inparanoid, Phylogenetics, Genome, Phylogenetic profiling, Phylogenetic tree, Biology, Computational biology, Protein family, Molecular evolution, Conserved sequence, Genetics
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publication . Other literature type . Article . 1997

A Genomic Perspective on Protein Families

Koonin, E. V.; Tatusov, R. L.; Lipman, D. J.;