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Towards feedback control of the cell-cycle across a population of yeast cells

Perrino, Giansimone; Fiore, Davide; Napolitano, Sara; di Bernardo, Mario; di Bernardo, Diego;
Open Access
<p>Abstract</p> <p>Cells are defined by their unique ability to self-replicate through cell division. This periodic process is known as the cell-cycle and it happens with a defined period in each cell. The budding yeast divides asymmetrically with a mother cell generating multiple daughter cells. Within the cell population each cell divides with the same period but asynchronously. Here, we investigate the problem of synchronising the cell-cycle across a population of yeast cells through a microfluidics-based feedback control platform. We propose a theoretical and experimental approach for cell-cycle control by considering a yeast strain that can be forced to st...
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Funded by
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020
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