publication . Article . 2014

Could 18 F-DPA-714 PET imaging be interesting to use in the early post-stroke period?

Jean-Philippe Cottier; Johnny Vercouillie; Vincent Camus; Michael Kassiou; Nicolas Arlicot; Maria-Joao Ribeiro; Denis Guilloteau; Séverine Debiais; I. Bonnaud; Samuel D. Banister;
Open Access English
  • Published: 06 Jun 2014 Journal: EJNMMI Research, volume 4, issue 1 (issn: 2191-219X, Copyright policy)
  • Publisher: Springer Nature
Abstract
BACKGROUND: Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase the functional prognosis by restoring brain reperfusion. However, a better understanding of the pathophysiology of stroke should help to identify potential new therapeutic targets. Stroke is known to induce an inflammatory brain reaction that involves overexpression of the 18-kDa translocator protein (TSPO) in glial cells and infiltrated leukocytes, which can be visualised by positron emission tomography (PET). We aimed to evaluate post-stroke ne...
Subjects
free text keywords: Radiology Nuclear Medicine and imaging, Neuroinflammation, Original Research, 18 F-DPA-714, 18 F-DPA-714, PET, Pathology, medicine.medical_specialty, medicine, Magnetic resonance imaging, medicine.diagnostic_test, Lesion, medicine.symptom, Nuclear medicine, business.industry, business, Translocator protein, biology.protein, biology, Positron emission tomography, DPA-714, Blood–brain barrier, medicine.anatomical_structure, Infarction, medicine.disease, Stroke
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
40 references, page 1 of 3

Bikbov, B, Perico, N, Remuzzi, G. Mortality landscape in the global burden of diseases, injuries and risk factors study. Eur J Intern Med. 2014; 4: 1-5 [OpenAIRE] [PubMed] [DOI]

The state of US health, 1990–2010: burden of diseases, injuries, and risk factors. JAMA. 2013; 4: 591-608 [OpenAIRE] [DOI]

Donnan, GA, Fisher, M, Macleod, M, Davis, SM. Stroke. Lancet. 2008; 4: 1612-1623 [PubMed] [DOI]

Lo, EH, Dalkara, T, Moskowitz, MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 2003; 4: 399-415 [OpenAIRE] [PubMed] [DOI]

Lai, AY, Todd, KG. Hypoxia-activated microglial mediators of neuronal survival are differentially regulated by tetracyclines. Glia. 2006; 4: 809-816 [OpenAIRE] [PubMed] [DOI]

Tymianski, M. Novel approaches to neuroprotection trials in acute ischemic stroke. Stroke. 2013; 4: 2942-2950 [OpenAIRE] [PubMed] [DOI]

Deddens, LH, Van Tilborg, GA, Mulder, WJ, De Vries, HE, Dijkhuizen, RM. Imaging neuroinflammation after stroke: current status of cellular and molecular MRI strategies. Cerebrovasc Dis. 2012; 4: 392-402 [OpenAIRE] [PubMed] [DOI]

Jacobs, AH, Tavitian, B. Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab. 2012; 4: 1393-1415 [OpenAIRE] [PubMed] [DOI]

Thiel, A, Heiss, WD. Imaging of microglia activation in stroke. Stroke. 2011; 4: 507-512 [PubMed] [DOI]

del Zoppo, GJ, Pessin, MS, Mori, E, Hacke, W. Thrombolytic intervention in acute thrombotic and embolic stroke. Semin Neurol. 1991; 4: 368-384 [OpenAIRE] [PubMed] [DOI]

Mabuchi, T, Kitagawa, K, Ohtsuki, T, Kuwabara, K, Yagita, Y, Yanagihara, T, Hori, M, Matsumoto, M. Contribution of microglia/macrophages to expansion of infarction and response of oligodendrocytes after focal cerebral ischemia in rats. Stroke. 2000; 4: 1735-1743 [OpenAIRE] [PubMed] [DOI]

Danton, GH, Dietrich, WD. Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol. 2003; 4: 127-136 [OpenAIRE] [PubMed]

Rallidis, LS, Vikelis, M, Panagiotakos, DB, Rizos, I, Zolindaki, MG, Kaliva, K, Kremastinos, DT. Inflammatory markers and in-hospital mortality in acute ischaemic stroke. Atherosclerosis. 2006; 4: 193-197 [OpenAIRE] [PubMed] [DOI]

Worthmann, H, Tryc, AB, Deb, M, Goldbecker, A, Ma, YT, Tountopoulou, A, Lichtinghagen, R, Weissenborn, K. Linking infection and inflammation in acute ischemic stroke. Ann N Y Acad Sci. 2010; 4: 116-122 [OpenAIRE] [PubMed] [DOI]

Papadopoulos, V, Baraldi, M, Guilarte, TR, Knudsen, TB, Lacapère, JJ, Lindemann, P, Norenberg, MD, Nutt, D, Weizman, A, Zhang, MR, Gavish, M. Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006; 4: 402-409 [OpenAIRE] [PubMed] [DOI]

40 references, page 1 of 3
Related research
Abstract
BACKGROUND: Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase the functional prognosis by restoring brain reperfusion. However, a better understanding of the pathophysiology of stroke should help to identify potential new therapeutic targets. Stroke is known to induce an inflammatory brain reaction that involves overexpression of the 18-kDa translocator protein (TSPO) in glial cells and infiltrated leukocytes, which can be visualised by positron emission tomography (PET). We aimed to evaluate post-stroke ne...
Subjects
free text keywords: Radiology Nuclear Medicine and imaging, Neuroinflammation, Original Research, 18 F-DPA-714, 18 F-DPA-714, PET, Pathology, medicine.medical_specialty, medicine, Magnetic resonance imaging, medicine.diagnostic_test, Lesion, medicine.symptom, Nuclear medicine, business.industry, business, Translocator protein, biology.protein, biology, Positron emission tomography, DPA-714, Blood–brain barrier, medicine.anatomical_structure, Infarction, medicine.disease, Stroke
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
40 references, page 1 of 3

Bikbov, B, Perico, N, Remuzzi, G. Mortality landscape in the global burden of diseases, injuries and risk factors study. Eur J Intern Med. 2014; 4: 1-5 [OpenAIRE] [PubMed] [DOI]

The state of US health, 1990–2010: burden of diseases, injuries, and risk factors. JAMA. 2013; 4: 591-608 [OpenAIRE] [DOI]

Donnan, GA, Fisher, M, Macleod, M, Davis, SM. Stroke. Lancet. 2008; 4: 1612-1623 [PubMed] [DOI]

Lo, EH, Dalkara, T, Moskowitz, MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 2003; 4: 399-415 [OpenAIRE] [PubMed] [DOI]

Lai, AY, Todd, KG. Hypoxia-activated microglial mediators of neuronal survival are differentially regulated by tetracyclines. Glia. 2006; 4: 809-816 [OpenAIRE] [PubMed] [DOI]

Tymianski, M. Novel approaches to neuroprotection trials in acute ischemic stroke. Stroke. 2013; 4: 2942-2950 [OpenAIRE] [PubMed] [DOI]

Deddens, LH, Van Tilborg, GA, Mulder, WJ, De Vries, HE, Dijkhuizen, RM. Imaging neuroinflammation after stroke: current status of cellular and molecular MRI strategies. Cerebrovasc Dis. 2012; 4: 392-402 [OpenAIRE] [PubMed] [DOI]

Jacobs, AH, Tavitian, B. Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab. 2012; 4: 1393-1415 [OpenAIRE] [PubMed] [DOI]

Thiel, A, Heiss, WD. Imaging of microglia activation in stroke. Stroke. 2011; 4: 507-512 [PubMed] [DOI]

del Zoppo, GJ, Pessin, MS, Mori, E, Hacke, W. Thrombolytic intervention in acute thrombotic and embolic stroke. Semin Neurol. 1991; 4: 368-384 [OpenAIRE] [PubMed] [DOI]

Mabuchi, T, Kitagawa, K, Ohtsuki, T, Kuwabara, K, Yagita, Y, Yanagihara, T, Hori, M, Matsumoto, M. Contribution of microglia/macrophages to expansion of infarction and response of oligodendrocytes after focal cerebral ischemia in rats. Stroke. 2000; 4: 1735-1743 [OpenAIRE] [PubMed] [DOI]

Danton, GH, Dietrich, WD. Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol. 2003; 4: 127-136 [OpenAIRE] [PubMed]

Rallidis, LS, Vikelis, M, Panagiotakos, DB, Rizos, I, Zolindaki, MG, Kaliva, K, Kremastinos, DT. Inflammatory markers and in-hospital mortality in acute ischaemic stroke. Atherosclerosis. 2006; 4: 193-197 [OpenAIRE] [PubMed] [DOI]

Worthmann, H, Tryc, AB, Deb, M, Goldbecker, A, Ma, YT, Tountopoulou, A, Lichtinghagen, R, Weissenborn, K. Linking infection and inflammation in acute ischemic stroke. Ann N Y Acad Sci. 2010; 4: 116-122 [OpenAIRE] [PubMed] [DOI]

Papadopoulos, V, Baraldi, M, Guilarte, TR, Knudsen, TB, Lacapère, JJ, Lindemann, P, Norenberg, MD, Nutt, D, Weizman, A, Zhang, MR, Gavish, M. Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006; 4: 402-409 [OpenAIRE] [PubMed] [DOI]

40 references, page 1 of 3
Related research
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