publication . Article . 1977

Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat

Harry J. Karavolas; Robert W. Goy; Israel Hanukoglu;
Open Access
  • Published: 01 Apr 1977
Abstract
Specific brain regions, namely, thalamus, tectum, tegmentum, cerebellum, medulla and pineal, from five proestrous rats were incubated for 30 min with [3H]progesterone. After reverse isotopic dilution analysis, the following metabolites were identified in all incubations by purification to constant specific activity, derivative formation and/or gas liquid chromatography trapping: [3H]5alpha-pregnane-3, 20-dione (10-20% of the starting substrate except pineal -- 0.7%), [3H]3alpha-hydroxy-5alpha-pregnan-20-one (1.6-3.8% except for pineal -- 0.5%) and [3H]20alpha-hydroxy-4-pregnen-3-one (0.05-0.11%). Preliminary results from the corpus collosum incubation indicated ...
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Medical Subject Headings: endocrine system
free text keywords: Developmental Biology, General Neuroscience, Molecular Biology, Clinical Neurology, Endocrinology, medicine.medical_specialty, medicine, Corpus callosum, Tectum, Medulla, Tegmentum, Pineal gland, medicine.anatomical_structure, Biology, Internal medicine, Cerebellum, Medulla oblongata, Dehydrogenase
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Article . 1977
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Brain Research
Article . 2003
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