publication . Article . 1977

Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat

Name: Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat
Keywords: Developmental Biology, General Neuroscience, Molecular Biology, Clinical Neurology

Harry J. Karavolas; Robert W. Goy; Israel Hanukoglu;

Open Access

Published: 01 Apr 1977

Summary

Abstract

Specific brain regions, namely, thalamus, tectum, tegmentum, cerebellum, medulla and pineal, from five proestrous rats were incubated for 30 min with [3H]progesterone. After reverse isotopic dilution analysis, the following metabolites were identified in all incubations by purification to constant specific activity, derivative formation and/or gas liquid chromatography trapping: [3H]5alpha-pregnane-3, 20-dione (10-20% of the starting substrate except pineal -- 0.7%), [3H]3alpha-hydroxy-5alpha-pregnan-20-one (1.6-3.8% except for pineal -- 0.5%) and [3H]20alpha-hydroxy-4-pregnen-3-one (0.05-0.11%). Preliminary results from the corpus collosum incubation indicated ...

Persistent Identifiers

doi: 10.1016/0006-8993(77)90624-2

Subjects

Medical Subject Headings: endocrine system

free text keywords: Developmental Biology, General Neuroscience, Molecular Biology, Clinical Neurology, Endocrinology, medicine.medical_specialty, medicine, Corpus callosum, Tectum, Medulla, Tegmentum, Pineal gland, medicine.anatomical_structure, Biology, Internal medicine, Cerebellum, Medulla oblongata, Dehydrogenase

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