publication . Article . Other literature type . 2011

Toxicokinetic and toxicodynamic (TK/TD) evaluation to determine and predict the neurotoxicity of artemisinins

Li, Qigui; Hickman, Mark;
  • Published: 01 Jan 2011
  • Publisher: Elsevier BV
Abstract
Abstract Studies with laboratory animals have demonstrated fatal neurotoxicity that is associated with administration of artemether (AM) and arteether (AE) intramuscularly or artelinic acid (AL) orally. Toxicokinetic studies showed oil-soluble artemisinins form a depot at the intramuscular injection sites, which is associated with fascia inflammation in muscles. Oral administration of AL induces a gastrointestinal toxicity that is linked with delayed gastric emptying. These effects suggest that the exposure time of artemisinins was extended due to drug accumulation in blood, and this in turn resulted in neurotoxicity. In the present report, the drug exposure tim...
Subjects
free text keywords: Toxicology, Pharmacology, Intramuscular injection, Artelinic acid, medicine.medical_treatment, medicine, Toxicity, Pharmacokinetics, Oral administration, Artemether, medicine.drug, business.industry, business, Neurotoxicity, medicine.disease, Artemisinins
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Article . 2011
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http://dx.doi.org/10.1016/j.to...
Other literature type . 2011
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publication . Article . Other literature type . 2011

Toxicokinetic and toxicodynamic (TK/TD) evaluation to determine and predict the neurotoxicity of artemisinins

Li, Qigui; Hickman, Mark;