publication . Other literature type . Article . 2018

Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures.

Rieder, Bernhard; Weihs, Anna M.; Weidinger, Adelheid; Szwarc, Dorota; Nürnberger, Sylvia; Redl, Heinz; Rünzler, Dominik; Huber-Gries, Carina; Teuschl, Andreas H.;
Open Access English
  • Published: 19 Nov 2018
  • Publisher: Zenodo
Abstract
Abstract Osteoarthritis (OA) is one of the most common causes of disability and represents a major socio-economic burden. Despite intensive research, the molecular mechanisms responsible for the initiation and progression of OA remain inconclusive. In recent years experimental findings revealed elevated levels of reactive oxygen species (ROS) as a major factor contributing to the onset and progression of OA. Hence, we designed a hydrostatic pressure bioreactor system that is capable of stimulating cartilage cell cultures with elevated ROS levels. Increased ROS levels in the media did not only lead to an inhibition of glycosaminoglycans and collagen II formation ...
Subjects
free text keywords: Osteoarthritis, Bioreactor, Article, Medicine, R, Science, Q, Multidisciplinary
Download fromView all 7 versions
Zenodo
Other literature type . 2018
Provider: Datacite
ZENODO
Article . 2018
Provider: ZENODO
Scientific Reports
Article . 2018
Provider: Crossref
72 references, page 1 of 5

Helmick, CG. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum.. 2008; 58: 15-25 [PubMed] [DOI]

Lawrence, RC. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum.. 2008; 58: 26-35 [OpenAIRE] [PubMed] [DOI]

Berenbaum, F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthr. Cartil.. 2013; 21: 16-21 [OpenAIRE] [PubMed] [DOI]

Dobson, GP. Defining the osteoarthritis patient: back to the future. Osteoarthr. Cartil.. 2018; 26: 1003-1007 [OpenAIRE] [PubMed] [DOI]

Liu-Bryan, R, Terkeltaub, R. Emerging regulators of the inflammatory process in osteoarthritis. Nat. Rev. Rheumatol.. 2015; 11: 35-44 [OpenAIRE] [PubMed] [DOI]

Kim, SJ. Therapeutic effects of neuropeptide substance P coupled with self-assembled peptide nanofibers on the progression of osteoarthritis in a rat model. Biomaterials. 2016; 74: 119-30 [OpenAIRE] [PubMed] [DOI]

Smith, G, Myers, SL, Brandt, KD, Mickler, EA, Albrecht, ME. Effect of intraarticular hyaluronan injection on vertical ground reaction force and progression of osteoarthritis after anterior cruciate ligament transection. J. Rheumatol.. 2005; 32: 325-34 [PubMed]

Johnson, CI, Argyle, DJ, Clements, DN. In vitro models for the study of osteoarthritis. Vet. J.. 2016; 209: 40-9 [OpenAIRE] [PubMed] [DOI]

Weber, JF, Waldman, SD. Calcium signaling as a novel method to optimize the biosynthetic response of chondrocytes to dynamic mechanical loading. Biomech. Model. Mechanobiol.. 2014; 13: 1387-1397 [OpenAIRE] [PubMed] [DOI]

Scherer, K, Schünke, M, Sellckau, R, Hassenpflug, J, Kurz, B. The influence of oxygen and hydrostatic pressure on articular chondrocytes and adherent bone marrow cells in vitro. Biorheology. 2004; 41: 323-33 [PubMed]

Fioravanti, A. Morphological, immunocytochemical and biochemical studies in human osteoarthritic chondrocytes exposed to IL-1b and cyclical hydrostatic pressure. Clin. Exp. Rheumatol.. 2007; 25: 690-5 [PubMed]

Knight, MM, Toyoda, T, Lee, DA, Bader, DL. Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. J. Biomech.. 2006; 39: 1547-1551 [OpenAIRE] [PubMed] [DOI]

Pascarelli, NA, Collodel, G, Moretti, E, Cheleschi, S, Fioravanti, A. Changes in ultrastructure and cytoskeletal aspects of human normal and osteoarthritic chondrocytes exposed to interleukin-1β and cyclical hydrostatic pressure. Int. J. Mol. Sci.. 2015; 16: 26019-26034 [OpenAIRE] [PubMed] [DOI]

Henrotin, Y, Kurz, B, Aigner, T. Oxygen and reactive oxygen species in cartilage degradation: Friends or foes?. Osteoarthr. Cartil.. 2005; 13: 643-654 [OpenAIRE] [PubMed] [DOI]

Ziskoven, C. Oxidative stress in secondary osteoarthritis: from cartilage destruction to clinical presentation. Orthop. Rev. (Pavia).. 2010; 2: e23 [OpenAIRE] [PubMed] [DOI]

72 references, page 1 of 5
Abstract
Abstract Osteoarthritis (OA) is one of the most common causes of disability and represents a major socio-economic burden. Despite intensive research, the molecular mechanisms responsible for the initiation and progression of OA remain inconclusive. In recent years experimental findings revealed elevated levels of reactive oxygen species (ROS) as a major factor contributing to the onset and progression of OA. Hence, we designed a hydrostatic pressure bioreactor system that is capable of stimulating cartilage cell cultures with elevated ROS levels. Increased ROS levels in the media did not only lead to an inhibition of glycosaminoglycans and collagen II formation ...
Subjects
free text keywords: Osteoarthritis, Bioreactor, Article, Medicine, R, Science, Q, Multidisciplinary
Download fromView all 7 versions
Zenodo
Other literature type . 2018
Provider: Datacite
ZENODO
Article . 2018
Provider: ZENODO
Scientific Reports
Article . 2018
Provider: Crossref
72 references, page 1 of 5

Helmick, CG. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum.. 2008; 58: 15-25 [PubMed] [DOI]

Lawrence, RC. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum.. 2008; 58: 26-35 [OpenAIRE] [PubMed] [DOI]

Berenbaum, F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthr. Cartil.. 2013; 21: 16-21 [OpenAIRE] [PubMed] [DOI]

Dobson, GP. Defining the osteoarthritis patient: back to the future. Osteoarthr. Cartil.. 2018; 26: 1003-1007 [OpenAIRE] [PubMed] [DOI]

Liu-Bryan, R, Terkeltaub, R. Emerging regulators of the inflammatory process in osteoarthritis. Nat. Rev. Rheumatol.. 2015; 11: 35-44 [OpenAIRE] [PubMed] [DOI]

Kim, SJ. Therapeutic effects of neuropeptide substance P coupled with self-assembled peptide nanofibers on the progression of osteoarthritis in a rat model. Biomaterials. 2016; 74: 119-30 [OpenAIRE] [PubMed] [DOI]

Smith, G, Myers, SL, Brandt, KD, Mickler, EA, Albrecht, ME. Effect of intraarticular hyaluronan injection on vertical ground reaction force and progression of osteoarthritis after anterior cruciate ligament transection. J. Rheumatol.. 2005; 32: 325-34 [PubMed]

Johnson, CI, Argyle, DJ, Clements, DN. In vitro models for the study of osteoarthritis. Vet. J.. 2016; 209: 40-9 [OpenAIRE] [PubMed] [DOI]

Weber, JF, Waldman, SD. Calcium signaling as a novel method to optimize the biosynthetic response of chondrocytes to dynamic mechanical loading. Biomech. Model. Mechanobiol.. 2014; 13: 1387-1397 [OpenAIRE] [PubMed] [DOI]

Scherer, K, Schünke, M, Sellckau, R, Hassenpflug, J, Kurz, B. The influence of oxygen and hydrostatic pressure on articular chondrocytes and adherent bone marrow cells in vitro. Biorheology. 2004; 41: 323-33 [PubMed]

Fioravanti, A. Morphological, immunocytochemical and biochemical studies in human osteoarthritic chondrocytes exposed to IL-1b and cyclical hydrostatic pressure. Clin. Exp. Rheumatol.. 2007; 25: 690-5 [PubMed]

Knight, MM, Toyoda, T, Lee, DA, Bader, DL. Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. J. Biomech.. 2006; 39: 1547-1551 [OpenAIRE] [PubMed] [DOI]

Pascarelli, NA, Collodel, G, Moretti, E, Cheleschi, S, Fioravanti, A. Changes in ultrastructure and cytoskeletal aspects of human normal and osteoarthritic chondrocytes exposed to interleukin-1β and cyclical hydrostatic pressure. Int. J. Mol. Sci.. 2015; 16: 26019-26034 [OpenAIRE] [PubMed] [DOI]

Henrotin, Y, Kurz, B, Aigner, T. Oxygen and reactive oxygen species in cartilage degradation: Friends or foes?. Osteoarthr. Cartil.. 2005; 13: 643-654 [OpenAIRE] [PubMed] [DOI]

Ziskoven, C. Oxidative stress in secondary osteoarthritis: from cartilage destruction to clinical presentation. Orthop. Rev. (Pavia).. 2010; 2: e23 [OpenAIRE] [PubMed] [DOI]

72 references, page 1 of 5
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