publication . Other literature type . Article . 2018

Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures

Sylvia Nürnberger; Carina Huber-Gries; Dorota Szwarc; Dominik Rünzler; Bernhard Rieder; Anna M. Weihs; Andreas H. Teuschl; Heinz Redl; Adelheid Weidinger;
Open Access English
  • Published: 19 Nov 2018
  • Publisher: Zenodo
Abstract Osteoarthritis (OA) is one of the most common causes of disability and represents a major socio-economic burden. Despite intensive research, the molecular mechanisms responsible for the initiation and progression of OA remain inconclusive. In recent years experimental findings revealed elevated levels of reactive oxygen species (ROS) as a major factor contributing to the onset and progression of OA. Hence, we designed a hydrostatic pressure bioreactor system that is capable of stimulating cartilage cell cultures with elevated ROS levels. Increased ROS levels in the media did not only lead to an inhibition of glycosaminoglycans and collagen II formation ...
free text keywords: Osteoarthritis, Bioreactor, Article, Multidisciplinary, Reactive oxygen species, chemistry.chemical_classification, chemistry, Mesenchymal stem cell, PI3K/AKT/mTOR pathway, Proinflammatory cytokine, Chondrogenesis, Cartilage, medicine.anatomical_structure, medicine, Cell biology, Hydrostatic pressure, MAPK/ERK pathway, lcsh:Medicine, lcsh:R, lcsh:Science, lcsh:Q
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Other literature type . 2018
Provider: Datacite
Other literature type . 2018
Provider: Datacite
Article . 2018
Provider: ZENODO
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