publication . Article . 2017

First in vivo MRI study on theranostic dendrimersomes

Miriam Filippi; Valeria Catanzaro; Deyssy Patrucco; Mauro Botta; Lorenzo Tei; Enzo Terreno;
Open Access English
  • Published: 28 Feb 2017
  • Country: Italy
Abstract
Abstract Amphiphilic Janus-dendrimers are able to self-assemble into nanosized vesicles named dendrimersomes. We recently synthesized the 3,5-C 12 -EG-(OH) 4 dendrimer that generates dendrimersomes with very promising safety and stability profiles, that can be loaded with different contrast agents for in vivo imaging. In this contribution, nanovesicles were loaded with both the Magnetic Resonance Imaging (MRI) reporter GdDOTAGA(C 18 ) 2 and the glucocorticoid drug Prednisolone Phosphate (PLP), in order to test their effective potential as theranostic nanocarriers on murine melanoma tumour models. The incorporation of GdDOTAGA(C 18 ) 2 into the membrane resulted ...
Subjects
free text keywords: Dendrimersomes, prednisolone phosphate, theranostic,, Dendrimersomes; Magnetic Resonance Imaging; Melanoma; Prednisolone Phosphate; Theranostic; 3003, Pharmaceutical Science, Magnetic resonance imaging, medicine.diagnostic_test, medicine, Dendrimer, In vitro, Vesicle, Melanoma, medicine.disease, Preclinical imaging, Nanocarriers, In vivo, Biomedical engineering, Nanotechnology, Biochemistry, Chemistry
Related Organizations
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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publication . Article . 2017

First in vivo MRI study on theranostic dendrimersomes

Miriam Filippi; Valeria Catanzaro; Deyssy Patrucco; Mauro Botta; Lorenzo Tei; Enzo Terreno;