publication . Article . 2003

Overview of structural genomics: from structure to function

Zhang, Chao; Kim, Sung-Hou;
Open Access
  • Published: 01 Feb 2003 Journal: Current Opinion in Chemical Biology, volume 7, pages 28-32 (issn: 1367-5931, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract The unprecedented increase in the number of new protein sequences arising from genomics and proteomics highlights directly the need for methods to rapidly and reliably determine the molecular and cellular functions of these proteins. One such approach, structural genomics, aims to delineate the total repertoire of protein folds, thereby providing three-dimensional portraits for all proteins in a living organism and to infer molecular functions of the proteins. The goal of obtaining protein structures on a genomic scale has motivated the development of high-throughput technologies for macromolecular structure determination, which have begun to produce st...
Subjects
free text keywords: Analytical Chemistry, Biochemistry, Biology, Sequence alignment, Bioinformatics, Proteomics, Genomics, Protein structure, Functional genomics, Protein Data Bank (RCSB PDB), Organism, Structural genomics
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publication . Article . 2003

Overview of structural genomics: from structure to function

Zhang, Chao; Kim, Sung-Hou;