publication . Article . 2001

Comprehensive analysis of citrate effects during plateletpheresis in normal donors

Sarah E. Greer; Stacey A. Cecco; Jaime Oblitas; Susan F. Leitman; Charles D. Bolan; Nadja N. Rehak;
Open Access
  • Published: 01 Sep 2001 Journal: Transfusion, volume 41, pages 1,165-1,171 (issn: 0041-1132, eissn: 1537-2995, Copyright policy)
  • Publisher: Wiley
BACKGROUND: Although plateletpheresis procedures are generally well tolerated, the clinical and metabolic consequences associated with rapid infusion of up to 10 g of citrate are underappreciated, and a comprehensive description of these events is not available. STUDY DESIGN AND METHODS: Clinical and laboratory changes were studied in seven healthy donors undergoing three 90-minute plateletpheresis procedures each, at continuous, fixed citrate infusion rates of 1.1, 1.4, and 1.6 mg per kg per minute. RESULTS: Serum citrate levels increased markedly with increasing citrate infusion rates and did not achieve a stable plateau. As citrate infusion rates increased, t...
free text keywords: Toxicity, Calcium, chemistry.chemical_element, chemistry, Urine, Sodium, Magnesium, Calcium metabolism, Endocrinology, medicine.medical_specialty, medicine, Plateletpheresis, Internal medicine, Renal physiology
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