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Computer-Aided Whole-Cell Design: Taking a Holistic Approach by Integrating Synthetic With Systems Biology

Marucci, Lucia; Barberis, Matteo; Karr, Jonathan; Ray, Oliver; Race, Paul R.; Andrade, Miguel de Souza; Grierson, Claire; Hoffmann, Stefan Andreas; Landon, Sophie; Rech, Elibio; ...
Open Access
<p>Abstract</p> <p>Computer-aided design (CAD) for synthetic biology promises to accelerate the rational and robust engineering of biological systems. It requires both detailed and quantitative mathematical and experimental models of the processes to (re)design biology, and software and tools for genetic engineering and DNA assembly. Ultimately, the increased precision in the design phase will have a dramatic impact on the production of designer cells and organisms with bespoke functions and increased modularity. CAD strategies require quantitative models of cells that can capture multiscale processes and link genotypes to phenotypes. Here, we present a perspec...
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Funded by
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020
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