Anticancer activity driven by drug linker modification in a polyglutamic acid-based combination-drug conjugate

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Arroyo‐Crespo, Juan J.; Deladriere, Coralie; Nebot, Vicent J.; Charbonnier, David; Masiá, Esther; Paul, Alison; James, Craig; Armiñán, Ana; Vicent, María J.;
  • Publisher: Wiley
  • Related identifiers: doi: 10.1002/adfm.201800931
  • Subject: polymer–drug conjugates | breast cancer | combination therapy | polymer therapeutics | polypeptides

Combination nanotherapies for the treatment of breast cancer permits synergistic drug targeting of multiple pathways. However, poor carrier degradability, poor synergism of the combined drugs, low drug release regulation, and a lack of control on final macromolecule sol... View more
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