publication . Article . Other literature type . 2015

Copolymerization Preparation Of Cationic Cyclodextrin Chiral Stationary Phases For Drug Enantioseparation In Chromatography

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Open Access
  • Published: 10 Jan 2015
  • Publisher: Zenodo
Abstract
Authors: Ren-Qi Wang, Teng-Teng Ong, Ke Huang, Weihua Tang & Siu-Choon Ng ### Abstract We described a facile and effective protocol wherein radical copolymerization is employed to covalently bond cationic β-cyclodextrin (β-CD) onto silica particles with extended linkage, resulting in a chiral stationary phase (IMPCSP) that can be used for the enantioseparation of racemic drugs in both high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC). Starting from commercially available chemicals, the IMPCSP is prepared in several steps: (i) reaction of β-CD with 1-(p-toluenesulfonyl)-imidazole to afford mono-6A-(p-toluenesul...
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Article . 2015
Provider: ZENODO
http://dx.doi.org/10.5281/zeno...
Other literature type . 2015
Provider: Datacite
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publication . Article . Other literature type . 2015

Copolymerization Preparation Of Cationic Cyclodextrin Chiral Stationary Phases For Drug Enantioseparation In Chromatography

sprotocols;