publication . Article . 2008

Neuroendocrine Properties of Adrenocortical Cells

M. Ehrhart-Bornstein; U. Hilbers;
Open Access
  • Published: 07 Nov 2008 Journal: Hormone and Metabolic Research, volume 30, pages 436-439 (issn: 0018-5043, eissn: 1439-4286, Copyright policy)
  • Publisher: Georg Thieme Verlag KG
Abstract
Recent data suggest that adrenocortical cells under pathological as well as under physiological conditions show neuroendocrine properties. Within the normal adrenal, this neuroendocrine differentiation seems to be restricted to cells of the zona glomerulosa and might be important for an autocrine regulation of adrenocortical function. In addition, such neuroendocrine differentiation is a common phenomenon in adrenocortical carcinomas and is therefore of clinical importance. In our studies, the expression of neuronal cell adhesion molecule (NCAM) could be shown in the zona glomerulosa of the normal human adrenal and in the human adrenocortical cell line NCI-H295 ...
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Subjects
Medical Subject Headings: endocrine system
free text keywords: Clinical Biochemistry, Biochemistry, Endocrinology, Diabetes and Metabolism, Endocrinology, Biochemistry, medical, General Medicine, Autocrine signalling, Neuronal Cell Adhesion Molecule, Neuroendocrine differentiation, Adrenal cortex, medicine.anatomical_structure, medicine, Endocrinology, medicine.medical_specialty, Synaptic vesicle, Synaptophysin, biology.protein, biology, Internal medicine, Zona glomerulosa, Neural cell adhesion molecule
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