publication . Article . 2007

Immune cell signaling aberrations in human lupus

Stamatis-Nick C. Liossis; Petros P. Sfikakis; George C. Tsokos;
Open Access
  • Published: 20 Dec 2007 Journal: Immunologic Research, volume 18, pages 27-39 (issn: 0257-277X, eissn: 1559-0755, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
A large array of heterogeneous aberrations of the immune system have been described in systemic lupus erythematosus (SLE). Since the function and the fate of the immune system cells are governed principally by the biochemical events that follow ligation of specialized cell-surface receptors, we will review in this article recent developments in our understanding of abnormalities in the biochemistry of signals generated either by the antigen-receptor complex or by systems of costimulatory cell-surface molecules, like the CD28/CTLA4:CD80/CD86 and the CD40:CD40L pairs found on the surface membrane of lupus immune cells.
Persistent Identifiers
Subjects
Medical Subject Headings: chemical and pharmacologic phenomenahemic and immune systemsimmune system diseasesskin and connective tissue diseases
free text keywords: Immunology, Cell signaling, Systemic lupus erythematosus, medicine.disease, medicine, CD86, Antigen, Cell biology, Biology, Autoimmunity, medicine.disease_cause, Lupus erythematosus, Immune system, Immune receptor
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