6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute micro- and astrogliosis in the nigrostriatal system but no Bioluminescence Imaging detectable alteration in adult neurogenesis.

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Fricke, Inga B; Viel, Thomas; Worlitzer, Maik M; Collmann, Franziska M; Vrachimis, Alexis; Faust, Andreas; Wachsmuth, Lydia; Faber, Cornelius; Dollé, Frédéric; Kuhlmann, Michael T; Schäfer, Klaus; Hermann, Sven; Schwamborn, Jens C; Jacobs, Andreas H;
  • Identifiers: doi: 10.1111/ejn.13232
  • Subject: [18F]DPA-714 | mouse | neuroinflammation | Parkinson's disease, , , , | 6-OHDA
    mesheuropmc: nervous system

Parkinson’s disease (PD) is a slowly progressing neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra (SN), leading to severe impairment in motor and non-motor functions. Endogenous subventricular zone (SVZ) neural stem cells constan... View more
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