publication . Other literature type . Article . 2016

6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis

Name: 6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis.
Keywords: General Neuroscience, Parkinson's disease, , , ,, 6-OHDA, [18F]DPA-714, mouse

Inga B. Fricke; Alexis Vrachimis; Franziska Melanie Collmann; Cornelius Faber; Lydia Wachsmuth; Andreas H. Jacobs; Maik M. A. Worlitzer; Jens Christian Schwamborn; Jens Christian Schwamborn; Michael T. Kuhlmann; ...

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Open Access

Published: 01 May 2016

Publisher: Wiley

Summary

Abstract

Parkinson's disease is a slowly progressing neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra (SN), leading to severe impairment in motor and non-motor functions. Endogenous subventricular zone (SVZ) neural stem cells constantly give birth to new cells that might serve as a possible source for regeneration in the adult brain. However, neurodegeneration is accompanied by neuroinflammation and dopamine depletion, potentially compromising regeneration. We therefore employed in vivo imaging methods to study striatal deafferentation (N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[(123) I]iodophenyl)nortropane single photon emission co...

doi: 10.1111/ejn.13232

Subjects

Medical Subject Headings: nervous system

free text keywords: General Neuroscience, Parkinson's disease, , , ,, 6-OHDA, [18F]DPA-714, mouse, Neurogenesis, Subventricular zone, medicine.anatomical_structure, medicine, Oxidopamine, chemistry.chemical_compound, chemistry, Substantia nigra, Dopaminergic Cell, Neurodegeneration, medicine.disease, Neuroinflammation, Neural stem cell, Neuroscience

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