publication . Other literature type . Article . 2016

6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis

Inga B. Fricke; Alexis Vrachimis; Franziska Melanie Collmann; Cornelius Faber; Lydia Wachsmuth; Andreas H. Jacobs; Maik M. A. Worlitzer; Jens Christian Schwamborn; Jens Christian Schwamborn; Michael T. Kuhlmann; ...
Open Access
  • Published: 01 May 2016
  • Publisher: Wiley
Abstract
Parkinson's disease is a slowly progressing neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra (SN), leading to severe impairment in motor and non-motor functions. Endogenous subventricular zone (SVZ) neural stem cells constantly give birth to new cells that might serve as a possible source for regeneration in the adult brain. However, neurodegeneration is accompanied by neuroinflammation and dopamine depletion, potentially compromising regeneration. We therefore employed in vivo imaging methods to study striatal deafferentation (N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[(123) I]iodophenyl)nortropane single photon emission co...
Subjects
Medical Subject Headings: nervous system
free text keywords: General Neuroscience, Parkinson's disease, , , ,, 6-OHDA, [18F]DPA-714, mouse, Neurogenesis, Subventricular zone, medicine.anatomical_structure, medicine, Oxidopamine, chemistry.chemical_compound, chemistry, Substantia nigra, Dopaminergic Cell, Neurodegeneration, medicine.disease, Neuroinflammation, Neural stem cell, Neuroscience
Related Organizations
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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