publication . Article . 2016

Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus

Josef Thalhamer; Richard Weiss; Barbara E. K. Klein; Heike Mrowetz; Ludwig Aigner; Sandra Scheiblhofer;
Open Access English
  • Published: 28 Jun 2016 Journal: Frontiers in Cellular Neuroscience, volume 10 (eissn: 1662-5102, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Allergies and their characteristic TH2-polarized inflammatory reactions affect a substantial part of the population. Since there is increasing evidence that the immune system modulates plasticity and function of the central nervous system (CNS), we investigated the effects of allergic lung inflammation on the hippocampus—a region of cellular plasticity in the adult brain. The focus of the present study was on microglia, the resident immune cells of the CNS, and on hippocampal neurogenesis, i.e., the generation of new neurons. C57BL/6 mice were sensitized with a clinically relevant allergen derived from timothy grass pollen (Phl p 5). As expected, allergic sensit...
Subjects
Medical Subject Headings: nervous system
free text keywords: Neuroscience, Original Research, allergy, neurogenesis, microglia, systemic inflammation, hippocampus, TH2 polarization, Subventricular zone, medicine.anatomical_structure, medicine, NeuN, biology.protein, biology, Immunology, Dentate gyrus, Doublecortin, Hippocampal formation, Cell biology, Subgranular zone
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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