publication . Article . Review . 2013

Energy metabolism and fertility—a balance preserved for female health

Name: Energy metabolism and fertility: a balance preserved for female health.
Keywords: Endocrinology, Diabetes and Metabolism, Endocrinology, Estrogen-receptor-alpha; polycystic-ovary-syndrome; nonalcoholic fatty liver; induced inflammatory response; cardiovascular risk-factors; turner-syndrome; insulin-resistance; gene-expression; food-intake; vitellogenin synthesis, Settore BIO/14 - Farmacologia, Settore BIO/09 - Fisiologia, Settore MED/13 - Endocrinologia

Roberta Fontana; Adriana Maggi; Sara Della Torre; Valeria Benedusi;

Open Access

Published: 22 Oct 2013 Journal: Nature Reviews Endocrinology, volume 10, pages 13-23 (issn: 1759-5029, eissn: 1759-5037,

Publisher: Springer Science and Business Media LLC

Country: Italy

Summary

Abstract

In female animals, energy metabolism and fertility are tightly connected, and reciprocally regulated. However, the relative contributions of metabolic and reproductive pathways have changed over the course of evolution. In oviparous animals, metabolic factors take precedence over fertility, enabling egg production to be inhibited in a nutritionally poor environment. By contrast, in placental mammals, the opposite occurs: the need to feed a developing embryo and neonate forces metabolic pathways to adapt to these reproductive needs. This physiological necessity explains why in female mammals alterations of gonadal activity, including age-dependent cessation of ov...

doi: 10.1038/nrendo.2013.203

pmid: 24146033

Subjects

free text keywords: Endocrinology, Diabetes and Metabolism, Endocrinology, Estrogen-receptor-alpha; polycystic-ovary-syndrome; nonalcoholic fatty liver; induced inflammatory response; cardiovascular risk-factors; turner-syndrome; insulin-resistance; gene-expression; food-intake; vitellogenin synthesis, Settore BIO/14 - Farmacologia, Settore BIO/09 - Fisiologia, Settore MED/13 - Endocrinologia, Female health, Energy metabolism, medicine.medical_specialty, medicine, Fertility, media_common.quotation_subject, media_common, business.industry, business, Disease prevention, Hormone replacement, Internal medicine, Physiology, Control female

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