publication . Article . Review . 2013

Energy metabolism and fertility—a balance preserved for female health

Roberta Fontana; Adriana Maggi; Sara Della Torre; Valeria Benedusi;
Open Access
  • Published: 22 Oct 2013 Journal: Nature Reviews Endocrinology, volume 10, pages 13-23 (issn: 1759-5029, eissn: 1759-5037, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
  • Country: Italy
In female animals, energy metabolism and fertility are tightly connected, and reciprocally regulated. However, the relative contributions of metabolic and reproductive pathways have changed over the course of evolution. In oviparous animals, metabolic factors take precedence over fertility, enabling egg production to be inhibited in a nutritionally poor environment. By contrast, in placental mammals, the opposite occurs: the need to feed a developing embryo and neonate forces metabolic pathways to adapt to these reproductive needs. This physiological necessity explains why in female mammals alterations of gonadal activity, including age-dependent cessation of ov...
free text keywords: Endocrinology, Diabetes and Metabolism, Endocrinology, Estrogen-receptor-alpha; polycystic-ovary-syndrome; nonalcoholic fatty liver; induced inflammatory response; cardiovascular risk-factors; turner-syndrome; insulin-resistance; gene-expression; food-intake; vitellogenin synthesis, Settore BIO/14 - Farmacologia, Settore BIO/09 - Fisiologia, Settore MED/13 - Endocrinologia, Female health, Energy metabolism, medicine.medical_specialty, medicine, Fertility, media_common.quotation_subject, media_common, business.industry, business, Disease prevention, Hormone replacement, Internal medicine, Physiology, Control female
Funded by
Role of Liver Estrogen Receptor in female Energy Metabolism, Reproduction and Aging: What About Your Liver Sexual Functions?
  • Funder: European Commission (EC)
  • Project Code: 322977
  • Funding stream: FP7 | SP2 | ERC
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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