publication . Other literature type . Preprint . Article . 2019

Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques.

Luis B. Barreiro; Noah D Simons; Mark L. Wilson; Noah Snyder-Mackler; Jordan N. Kohn; Paul L. Maurizio; Joaquín Sanz; Joaquín Sanz; Tawni Voyles; Jenny Tung; ...
Open Access
  • Published: 13 Aug 2019
  • Country: Spain
Abstract
<jats:title>Abstract</jats:title><jats:p>Social experiences are an important predictor of disease susceptibility and survival in humans and other social mammals. Chronic social stress is thought to generate a pro-inflammatory state characterized by elevated antibacterial defenses and reduced investment in antiviral defense. Here, we manipulated long-term social status in female rhesus macaques to show that social subordination alters the gene expression response to <jats:italic>ex vivo</jats:italic> bacterial and viral challenge. As predicted by current models, bacterial lipopolysaccharide polarizes the immune response such that low status corresponds to higher ...
Subjects
free text keywords: Multidisciplinary, Biological Embedding Across Timescales Special Feature, Social status, Gardiquimod, Immunology, Immune system, Proinflammatory cytokine, Social stress, Regulation of gene expression, Biology, Innate immune system, Gene expression, Interferon, medicine.drug, medicine
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
NIH| Stress and the Genome: Testing the Impact of Social Effects on Gene Regulation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01GM102562-01
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Support of Yerkes National Primate Research Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P51OD011132-53
  • Funding stream: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
,
NSERC
Project
  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
,
NSF| Genetic and Behavioral Predictors of Susceptibility to Social Stress
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1306134
  • Funding stream: Directorate for Social, Behavioral & Economic Sciences | SBE Office of Multidisciplinary Activities
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