publication . Article . Preprint . 2020

Multicellular Feedback Control of a Genetic Toggle-Switch in Microbial Consortia

Fiore, Davide; Salzano, Davide; Cristòbal-Cóppulo, Enric; Olm, Josep M.; di Bernardo, Mario;
Open Access
  • Published: 09 Jun 2020 Journal: IEEE Control Systems Letters, volume 5, pages 151-156 (eissn: 2475-1456, Copyright policy)
  • Publisher: Institute of Electrical and Electronics Engineers (IEEE)
  • Country: Spain
Abstract
© 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. We describe a multicellular approach to control a target cell population endowed with a bistable toggle-switch. The idea is to engineer a synthetic microbial consortium consisting of three different cell populations. In such a consortium, two populations, the Togglers, responding to so...
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Subjects
free text keywords: :Informàtica::Intel·ligència artificial [Àrees temàtiques de la UPC], :Matemàtiques i estadística::Anàlisi numèrica [Àrees temàtiques de la UPC], Multiagent systems, Artificial intelligence, Systems biology, genetic regulatory systems, cellular dynamics, modeling, Intel·ligència artificial, Multicellular organism, Feedback control, Control theory, Computer science, Toggle switch
Related Organizations
Funded by
EC| COSY-BIO
Project
COSY-BIO
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020 | RIA
Validated by funder
Communities
FET H2020FET OPEN: FET-Open research and innovation actions
FET H2020FET OPEN: Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
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bioRxiv
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