publication . Article . 1994

Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma

Chang, Y.; and Knowles, D. M.; Cesarman, E.; Ec, Cesarman; Pessin, M. S.; Lee, F.; Culpepper, J.; Knowles, D.; Moore, P. S.;
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  • Published: 16 Dec 1994 Journal: Science, volume 266, pages 1,865-1,869 (issn: 0036-8075, eissn: 1095-9203, Copyright policy)
  • Publisher: American Association for the Advancement of Science (AAAS)
Abstract
Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.
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Medical Subject Headings: virusesvirus diseasesbiochemical phenomena, metabolism, and nutrition
free text keywords: Multidisciplinary, Kaposi's sarcoma, medicine.disease, medicine, Gammaherpesvirinae, biology.organism_classification, biology, KSHV Inflammatory Cytokine Syndrome, Virology, AIDS-Related Kaposi Sarcoma, Virus, Kaposi's sarcoma-associated herpesvirus, medicine.disease_cause, Representational difference analysis, Rhadinovirus
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