publication . Article . 2017

Synthesis and functionalization of dextran-based single-chain nanoparticles in aqueous media

H. Grande; Vanessa Gómez-Vallejo; Raquel Gracia; Ana M. Benito; A. Pérez-San Vicente; Unai Cossío; Iraida Loinaz; Jordi Llop; Marco Marradi;
Open Access
  • Published: 16 Jan 2017
Water-dispersible dextran-based single-chain polymer nanoparticles (SCPNs) were prepared in aqueous media and under mild conditions. Radiolabeling of the resulting biocompatible materials allowed the study of lung deposition of aqueous aerosols after intratracheal nebulization by means of single-photon emission computed tomography (SPECT), demonstrating their potential use as imaging contrast agents. This project has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no 604434 (PneumoNP). This research was also supported by the Departamento de Desarrollo Económico...
free text keywords: Polymer, chemistry.chemical_classification, chemistry, Chemical engineering, Nanoparticle, Aqueous solution, Aqueous medium, Materials science, Emission computed tomography, medicine.diagnostic_test, medicine, Nanotechnology, Surface modification, Dextran, chemistry.chemical_compound, Single chain
Funded by
Nanotherapeutics to Treat Antibiotic Resistant Gram-Negative Pneumonia Infections
  • Funder: European Commission (EC)
  • Project Code: 604434
  • Funding stream: FP7 | SP1 | NMP
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