publication . Other literature type . Preprint . 2018

On The Well-Founded Enthusiasm For Soft Sweeps In Humans: A Reply To Harris, Sackman, And Jensen

Schrider, Daniel R; Kern, Andrew D;
Open Access
  • Published: 29 Oct 2018
  • Publisher: Zenodo
Abstract
A challenging but central question in population genetics is the detection of genomic regions underpinning recent adaptation. To this end, we recently devised a machine learning method, termed S/HIC, which detects both “hard” selective sweeps on de novo mutations and “soft” sweeps on standing genetic variation with high sensitivity and specificity, while being exceptionally robust to demographic model misspecification. We previously applied S/HIC to human population genomic data and uncovered evidence of a large number of recent selective sweeps across the genome, most of which we classified as soft sweeps. A critique of recent efforts to detect soft sweeps, inc...
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Zenodo
Other literature type . 2018
Provider: Datacite
ZENODO
Preprint . 2018
Provider: ZENODO
ZENODO
Preprint . 2018
Provider: ZENODO
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publication . Other literature type . Preprint . 2018

On The Well-Founded Enthusiasm For Soft Sweeps In Humans: A Reply To Harris, Sackman, And Jensen

Schrider, Daniel R; Kern, Andrew D;