publication . Article . Other literature type . 2018

Development of a human physiologically based pharmacokinetic (PBPK) model for phthalate (DEHP) and its metabolites: A bottom up modeling approach

Raju Prasad Sharma; Marta Schuhmacher; Vikas Kumar;
Open Access
  • Published: 01 Oct 2018
Abstract
Abstract DEHP exposure to human comes from different sources such as food, diet, cosmetics, toys, medical products, and food wraps. Recently, DEHP was categorized as non-persistent endocrine disrupting compounds (EDCs) by the world health organization (WHO). Rat experimental studies showed that phthalate and its metabolite(s) can cause hepatic, developmental and reproductive toxicity. In human, DEHP rapidly metabolizes into a toxic metabolite MEHP. This MEHP further metabolizes into the different chemical forms of 5OH-MEHP, 5oxo-MEHP, 5cx-MEPP and phthalic acid. A simple DEHP pharmacokinetics model has been developed, but with a limited number of metabolites. A ...
Subjects
Medical Subject Headings: endocrine system
free text keywords: DEHP, Endocrine disruptors, Human biomonitoring, Human health risk assessment, IVIVE, MEHP, PBPK, Pharmacokinetics, Toxicology, General Medicine, Biomonitoring, Independent data, Quantitative structure–activity relationship, Phthalate, chemistry.chemical_compound, chemistry, Physiologically based pharmacokinetic modelling, Metabolite, Reproductive toxicity, Biology, Biochemistry, Environmental chemistry
Funded by
EC| HEALS
Project
HEALS
Health and Environment-wide Associations based on Large population Surveys
  • Funder: European Commission (EC)
  • Project Code: 603946
  • Funding stream: FP7 | SP1 | ENV
,
EC| EuroMix
Project
EuroMix
EuroMix
  • Funder: European Commission (EC)
  • Project Code: 633172
  • Funding stream: H2020 | RIA
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publication . Article . Other literature type . 2018

Development of a human physiologically based pharmacokinetic (PBPK) model for phthalate (DEHP) and its metabolites: A bottom up modeling approach

Raju Prasad Sharma; Marta Schuhmacher; Vikas Kumar;