publication . Article . Other literature type . 2019

FORMULATION AND EVALUATION OF PLURONIC LECITHIN CLOTRIMAZOLE ORGANOGEL FOR TOPICAL DELIVERY

Sandeep C Atram*, Abhilash V Joshi1;
Open Access
  • Published: 04 Feb 2019
Abstract
Clotrimazole is a synthetic, imidazole derivate with broad-spectrum, antifungal drug which has been used in many skin and nail infections caused by fungi. The aim of the present study is to prepare and evaluate novel topical drug delivery of clotrimazole by using pluronic lecithin based organogel. Formulations were developed using 30% oil phase and 70% aqueous phase. The formulated organogels were evaluated for appearance by psycho-rheological, in vitro diffusion study, drug content, viscosity, spreadability and pH. It was found that the pH of all the formulations is in the range of to 6-7 that suits the skin pH, indicating skin compatibility. This is the primar...
Subjects
free text keywords: Pluronic Lecithin Organogel, Clotrimazole, Topical Delivery.
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ZENODO
Article . 2019
Provider: ZENODO
Zenodo
Other literature type . 2019
Provider: Datacite
Zenodo
Other literature type . 2019
Provider: Datacite
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