publication . Article . 2015

Role of adenoviruses in obesity

Atkinson RL; Jameson Voss;
Open Access
  • Published: 09 Sep 2015 Journal: Reviews in Medical Virology, volume 25, pages 379-387 (issn: 1052-9276, Copyright policy)
  • Publisher: Wiley
Abstract
Summary Five human adenovirus subtypes, Ad5, Ad9, Ad31, Ad36, and Ad37, and a non-human adenovirus, SMAM1, are linked to increased adiposity in vitro or in vivo. Experimental infection with Ad5, Ad36, and Ad37 produced excess adiposity or weight gain in animals. Ad9 and Ad31 increase fat storage in tissue culture but are not associated with animal or human obesity. Ad36 is the most extensively studied adipogenic adenovirus and is correlated with some measure of overweight/obesity in humans from multiple countries. The correlation is strongest and most consistent in children, but some studies have been negative in both children and adults. About 30% of overweight...
Subjects
Medical Subject Headings: viruses
free text keywords: Virology, Infectious Diseases
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