The many faces of the helix-turn-helix domain: Transcription regulation and beyond

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Aravind, L.; Anantharaman, Vivek; Balaji, Santhanam; Babu, M. Mohan; Iyer, Lakshminarayan M.;

The helix-turn-helix (HTH) domain is a common denominator in basal and specific transcription factors from the three super-kingdoms of life. At its core, the domain comprises of an open tri-helical bundle, which typically binds DNA with the 3rd helix. Drawing on the wea... View more
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