publication . Article . 2008

biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents

Patrick Caffrey; Jesus F Aparicio; Francisco Malpartida; Sergey B Zotchev;
Open Access
  • Published: 01 May 2008 Journal: Current Topics in Medicinal Chemistry, volume 8, pages 639-653 (issn: 1568-0266, Copyright policy)
  • Publisher: Bentham Science Publishers Ltd.
  • Country: Ireland
Abstract
Polyene macrolides are potent antifungal agents that are also active against parasites, enveloped viruses and prion diseases. They are medically important as antifungal antibiotics but their therapeutic use is limited by serious side effects. In recent years there has been considerable progress in genetic analysis and manipulation of the streptomycetes that produce nystatin, amphotericin B, candicidin, pimaricin and rimocidin/CE-108-related polyenes. This has led to engineered biosynthesis of several new polyenes that are not easily obtained as semi-synthetic derivatives. This review summarises recent advances made since the subject was last reviewed in 2003. Po...
Subjects
free text keywords: Polyenes, Polyketides, Engineered biosynthesis, Antifungals, Antiparasitic drugs, Drug Discovery, General Medicine, Amphotericin B, medicine.drug, medicine, Antifungal antibiotic, Candicidin, Nystatin, Biology, Biochemistry, Antiparasitic agent, Polyketide, Therapeutic index, Polyene, chemistry.chemical_compound, chemistry
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