Biosynthetic Engineering of Polyene Macrolides Towards Generation of Improved Antifungal and Antiparasitic Agents

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Caffrey, Patrick; Aparicio, Jesus F.; Malpartid, Francisco; Zotchev, Sergey B.;
  • Publisher: Bentham Science Publishers
  • Identifiers: doi: 10.2174/156802608784221479
  • Subject: Antiparasitic drugs | Polyenes | Antifungals | Polyketides | Engineered biosynthesis

Polyene macrolides are potent antifungal agents that are also active against parasites, enveloped viruses and prion diseases. They are medically important as antifungal antibiotics but their therapeutic use is limited by serious side effects. In recent years there has b... View more
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