publication . Article . Other literature type . 2009

Neural response to specific components of fearful faces in healthy and schizophrenic adults

Joaquim Radua; Mary L. Phillips; Tamara Russell; Natalia Lawrence; Nicolette Marshall; Sridevi Kalidindi; Wissam El-Hage; Colm McDonald; Vincent Giampietro; Michael Brammer; ...
Open Access
  • Published: 27 Aug 2009
Abstract
Perception of fearful faces is associated with functional activation of cortico-limbic structures, which has been found altered in individuals with psychiatric disorders such as schizophrenia, autism and major depression. The objective of this study was to isolate the brain response to the features of standardized fearful faces by incorporating principal component analysis (PCA) into the analysis of neuroimaging data of healthy volunteers and individuals with schizophrenia. At the first stage, the visual characteristics of morphed fearful facial expressions (FEEST, Young et al., 2002) were classified with PCA, which produced seven orthogonal factors, with some o...
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Medical Subject Headings: genetic structuresbehavioral disciplines and activitieseye diseases
free text keywords: Functional magnetic resonance imaging, medicine.diagnostic_test, medicine, Amygdala, medicine.anatomical_structure, Facial expression, Neuroimaging, Psychology, Perception, media_common.quotation_subject, media_common, Developmental psychology, Audiology, medicine.medical_specialty, Schizophrenia, medicine.disease, Schizophrenic Psychology, Autism
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Article . 2009
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