publication . Article . 1997

Environmental magnetic fields inhibit the antiproliferative action of tamoxifen and melatonin in a human breast cancer cell line

Name: Environmental magnetic fields inhibit the antiproliferative action of tamoxifen and melatonin in a human breast cancer cell line
Keywords: Biophysics, Physiology, Radiology Nuclear Medicine and imaging, General Medicine

Joan D. Harland; Robert P. Liburdy;

Open Access

Published: 01 Jan 1997 Journal: Bioelectromagnetics, volume 18, pages 555-562 (issn: 0197-8462, eissn: 1521-186X,

Publisher: Wiley

Summary

Abstract

We have previously reported that environmental-level magnetic fields (1.2 microT [12 milligauss], 60 Hz) block the growth inhibition of the hormone melatonin (10(-9) M) on MCF-7 human breast cancer cells in vitro. We now report that the same 1.2 microT, 60 Hz magnetic fields significantly block the growth inhibitory action of pharmacological levels of tamoxifen (10(-7) M). In biophysical studies we have taken advantage of Faraday's Law of Current Induction and tested whether the 1.2 microT magnetic field or the associated induced electric field is responsible for this field effect on melatonin and tamoxifen. We observe that the magnetic field component is associ...

Persistent Identifiers

doi: 10.1002/(sici)1521-186x(1997)18:8<555::aid-bem4>3.0.co;2-1 , 10.1002/(sici)1521-186x(1997)18:8

pmid: 9383244

Subjects

Medical Subject Headings: human activitiesequipment and supplies

free text keywords: Biophysics, Physiology, Radiology Nuclear Medicine and imaging, General Medicine, Biology, Growth inhibition, chemistry.chemical_compound, chemistry, Melatonin, medicine.drug, medicine, Cancer cell, Tamoxifen, Cell growth, Environmental exposure, Biological pathway, MCF-7, Pharmacology

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