publication . Article . 1997

Environmental magnetic fields inhibit the antiproliferative action of tamoxifen and melatonin in a human breast cancer cell line

Joan D. Harland; Robert P. Liburdy;
Open Access
  • Published: 01 Jan 1997 Journal: Bioelectromagnetics, volume 18, pages 555-562 (issn: 0197-8462, eissn: 1521-186X, Copyright policy)
  • Publisher: Wiley
Abstract
We have previously reported that environmental-level magnetic fields (1.2 microT [12 milligauss], 60 Hz) block the growth inhibition of the hormone melatonin (10(-9) M) on MCF-7 human breast cancer cells in vitro. We now report that the same 1.2 microT, 60 Hz magnetic fields significantly block the growth inhibitory action of pharmacological levels of tamoxifen (10(-7) M). In biophysical studies we have taken advantage of Faraday's Law of Current Induction and tested whether the 1.2 microT magnetic field or the associated induced electric field is responsible for this field effect on melatonin and tamoxifen. We observe that the magnetic field component is associ...
Subjects
Medical Subject Headings: human activitiesequipment and supplies
free text keywords: Biophysics, Physiology, Radiology Nuclear Medicine and imaging, General Medicine, Biology, Growth inhibition, chemistry.chemical_compound, chemistry, Melatonin, medicine.drug, medicine, Cancer cell, Tamoxifen, Cell growth, Environmental exposure, Biological pathway, MCF-7, Pharmacology
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