publication . Article . 2008

Viewing the Antigen-Induced Initiation of B-cell Activation in Living Cells

Pavel Tolar; Hae Won Sohn; Susan K. Pierce;
Open Access
  • Published: 15 Feb 2008
Abstract
Summary: The binding of antigen to the B-cell receptor (BCR) induces BCR clustering and signaling cascades that lead to the activation of a variety of genes associated with B-cell activation. Over the last several years, our understanding of the molecular details of the BCR signaling pathways have been considerably advanced; what remains only poorly understood are the molecular events that initiate BCR clustering and how clustering leads to activation. Here, we review our progress using live cell imaging technologies to view the earliest events that follow the B cell's binding of antigen. We provide a model for BCR clustering and B-cell activation that involves ...
Subjects
Medical Subject Headings: hemic and lymphatic diseases
free text keywords: Immunology, Immunology and Allergy, Live cell imaging, Signal transduction, Biology, Receptor clustering, B cell, medicine.anatomical_structure, medicine, Receptor, Antigen, Cell biology, Major histocompatibility complex, biology.protein, breakpoint cluster region
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