publication . Article . Part of book or chapter of book . 2005

DNA Mismatch Repair

Mark O'Driscoll; Odile Humbert; Peter Karran;
Open Access
  • Published: 18 Mar 2005 Journal: Structure, volume 8, issue 12, pages R237-R241 (issn: 0969-2126, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Studies of human mismatch repair were stimulated by the finding that mutations in genes encoding mismatch repair factors underlie the inherited predisposition to colorectal and other cancers in the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome and occur quite commonly in apparently sporadic tumours. Mismatch repair contributes to the fidelity of replication and thereby to the maintenance of acceptable spontaneous mutation rates. Tumours are considered to evolve by the successive accumulation of mutations in several key genes. The mutator phenotype associated with mismatch repair coincided neatly with the apparent requirement for a mutator effect...
Subjects
free text keywords: Molecular Biology, Structural Biology, Biochemistry, MutS-1, Nucleotide excision repair, DNA, chemistry.chemical_compound, chemistry, Biology, MutS DNA Mismatch-Binding Protein, Genome, Genetics, DNA mismatch repair, Replication protein A, DNA repair, Epigenetics, Human system, Gene, Cell, medicine.anatomical_structure, medicine, Microsatellite instability, medicine.disease, Werner syndrome, Error correcting, MSH3, DNA replication, Mismatch Repair Pathway, Base Pair Mismatch, MutL Proteins, Proofreading
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